(1) 如果先行词是all, much, anything, something, nothing, everything, little, none等不定代词，关系代词一般只用that，不用which。例如：
All the people that are present burst into tears.
(2) 如果先等词被形容词最高级以及first, last, any, only, few, mush, no, some, very等词修饰，关系代词常用that,不用which, who，或whom。例如：
(3) 非限制性定语从句中，不能用关系代词that,作宾语用的关系代词也不能省略。例如：
There are about seven million people taking part in the election, most of whom、are well educated.
(4) which还有一种特殊用法，它可以引导从句修饰前面的整个主句，代替主句所表示的整体概念或部分概念。在这种从句中，which可以作主语，也可以作宾语或表语，多数情况下意思是与and this 相似，并可以指人。例如：
He succeeded in the competition, which made his parents very happy.
(5) that可指人或物，在从句中作表语，(指人作主语时多用who)仅用于限制性定语从句中。
(6) which可作表语，既可指人，以可指物。指人时，一般指从事某种职业或是有种特征.品性或才能的人。Which引导的定语从句可以限制性的，也可以是非限制性的。
(7) 如果作先作词的集体名词着眼于集体的整体，关系代词用which;若是指集体中的各个成员，则用who。
(8) 先行词有两个，一个指人，一个指物，关系代词应该用that。例如：
The boy and the dog that are in the picture are very lovely.
(9) 如果先行词是anyone, anybody, everyone, everybody, someone, somebody,关系代词应该用 who 或whom，不用 which。例如：
Is there anyone here who will go with you?
3.介词+关系代词是一个普遍使用的结构
(1) 介词+关系代词可以引导限制性定语从句，也可以引导非限制性定语从句。介词+关系代词结构中的介词可以是 in, on, about, from, for, with, to at, of, without 等，关系代词只可用whom或 which,不可用 that 。
(2) from where为介词+关系副词结构，但也可以引导定语从句。例如：
We stood at the top of the hill, from where we can see the town..
(3) 像listen to, look at, depend on, pay attention to, take care of等固定短语动词，在定语从句中一般不宜将介词与动词分开。例如：
This is the boy whom she has taken care of.